Immuno-pathogenesis of nCOVID-19 and a possible host-directed therapy including anti-inflammatory and anti-viral prostaglandin (PG J
| Autor: | Shakeel, Shahzad, Mark, Willcox |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Host Microbial Interactions
Prostaglandin D2 SARS-CoV-2 viruses Pneumonia Viral Anti-Inflammatory Agents Immuno-pathology COVID-19 Anti-inflammatory and anti-viral prostaglandin Antiviral Agents Models Biological Article COVID-19 Drug Treatment Translational Research Biomedical Betacoronavirus Animals Humans Coronavirus Infections Pandemics |
| Zdroj: | Medical Hypotheses |
| ISSN: | 1532-2777 |
| Popis: | Coronaviruses including severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2, also known as 2019-nCoV especially in China) replicate and divide in host cells. During this they are partly hidden from the innate immune responses although inflammatory consequences of viral replication still occur. We propose that anti-inflammatory antiviral prostaglandins may not only restrict viral replication but also prevent inflammatory responses in the lungs and other vital organs that are known to be part of the immuno-pathogenesis of coronavirus disease-19 (COVID-19). The combination of anti-inflammatory antiviral prostaglandins with interferons may lead to the clearance of viruses inside growth-restricted infected cells. However, further experimental studies and clinical trials should be conducted to evaluate the safety and efficacy of these possible therapies. |
| Databáze: | OpenAIRE |
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