| Autor: |
Marcia Alessandra Arantes, Marques, Bruno Henrique Lopes Botelho, Lourenço, Michelle de Paula, Reis, Karoline Bach, Pauli, André Luiz, Soares, Salviano Tramontin, Belettini, Guilherme, Donadel, Rhanany Alan Calloi, Palozi, Diego Lacir, Froehlich, Francislaine Aparecida Dos Reis, Lívero, Arquimedes, Gasparotto Junior, Emerson Luiz Botelho, Lourenço |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of medicinal food. 22(3) |
| ISSN: |
1557-7600 |
| Popis: |
Osteoporosis is a systemic bone disease that is characterized by impairments in bone strength that predispose an individual to a higher risk of fractures. Despite the various etiologies, undoubtedly the most important factors are aging of the population and hypogonadism. Although several therapeutic options are available, pharmacological treatments have some risks. Among these are increases in the incidence of thrombosis, breast cancer, ovarian cancer, endometrial cancer, and muscle injury, among others. Herbal medication may be an alternative for the treatment of osteoporosis. Thus, the aim of this study was to evaluate the therapeutic effect of a standardized extract of Tribulus terrestris L. (TT) on ovariectomy (OVX)-induced bone loss in rats. Female rats were first subjected to OVX and treated with TT (3, 30, and 300 mg/[kg·day]) or furosemide (25 mg/kg) orally for 28 days. Bone densitometry and tibial histology were performed, and acute renal function and testosterone, dehydroepiandrosterone (DHEA), and estradiol levels were assessed. Prolonged treatment with TT stimulated bone mass gain in all ovariectomized animals, raising bone mass to levels that were similar to sham-operated rats. DHEA levels significantly increased in TT-treated rats. The TT group also had lower calcium (Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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