Heme oxygenase activity and some indices of antioxidant protection in rat liver and kidney in glycerol model of rhabdomyolysis

Autor:	P A, Kaliman, E V, Strel'chenko, I V, Nikitchenko, V P, Filimonenko
Rok vydání:	2002
Předmět:	Liver Superoxide Dismutase Spectrum Analysis Heme Oxygenase (Decyclizing) Animals Heme Rats Wistar Catalase Kidney Glutathione Oxidation-Reduction Rhabdomyolysis Rats
Zdroj:	Bulletin of experimental biology and medicine. 135(1)
ISSN:	0007-4888
Popis:	Activity of heme oxygenase, superoxide dismutase, and catalase, the content of reduced glutathione and total heme in the liver and kidneys, and serum absorption spectrum in the Soret band were studied in rats with glycerol-induced rhabdomyolysis. Glycerol increased the content of heme-containing metabolites in the serum and the total heme content in the liver and kidneys, and decreased the content of reduced glutathione and catalase activity in the examined organs. Superoxide dismutase activity increased in the liver and decreased in the kidneys. Heme oxygenase activity increased in the liver and kidneys 2 and 6 h postinjection, respectively. The effects of heme delivered to the liver and kidneys from the vascular bed on the antioxidant defense and heme oxygenase activity were studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2c179443d5d7fd359b7b7d0f21009581 https://pubmed.ncbi.nlm.nih.gov/12717508 Zobrazit plný text záznamu Full text from SpringerLink