| Autor: |
Amir, Tajbakhsh, Zahra, Farjami, Susan, Darroudi, Seyed Hasan, Ayati, Fatemeh, Vakili, Mahla, Asghari, Maliheh, Alimardani, Soheila, Abedini, Mohammad Mahdi, Kushyar, Alireza, Pasdar |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
EXCLI Journal |
| ISSN: |
1611-2156 |
| Popis: |
TOX3 and FOXA1 proteins are believed to be involved in the susceptibility of breast cancer. rs4784227-CASC16 and rs4782447-ACSF3, as single nucleotide polymorphisms (SNPs), located at the 16q may affect the FOXA1 DNA binding sequence change and therefore may enhance the FOXA1-binding affinity to the promoter of TOX3 gene. This study aimed to investigate the association of these SNPs/haplotypes with breast cancer susceptibility in an Iranian population. We conducted a case-control study of 1072 blood samples (505 breast cancer patients and 567 controls). Genotyping of rs4784227-CASC16 and rs4782447-ACSF3 SNPs was carried out by ARMS-PCR. Moreover, statistical analysis was done using SPSS version 20.0 (IBM Inc., Chicago, IL, USA), PHASE v 2.1 and SNP analyser 2.0. There was a strongly significant statistical association between alleles and genotypes of rs4784227-CASC16 with breast cancer risk in our study population (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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