Involvement of BMP and Wnt Signals Leadingto Epithelial-Mesenchymal Transition in Colon Adenocarcinoma with Heterotopic Ossification

Autor:	Naho, Katono, Masumi, Tsuda, Jun, Suzuka, Yoshitaka, Oda, Lei, Wang, Zen-Ichi, Tanei, Mishie, Tanino, Takanobu, Ohata, Eisuke, Nagabuchi, Yusuke, Ishida, Shunsuke, Kimura, Toshihiko, Iwanaga, Shinya, Tanaka
Rok vydání:	2021
Předmět:	Male Epithelial-Mesenchymal Transition Glycogen Synthase Kinase 3 beta Osteoblasts Colon Ossification Heterotopic Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 Adenocarcinoma Colonic Neoplasms Humans Wnt Signaling Pathway beta Catenin Aged
Zdroj:	Annals of clinical and laboratory science. 51(2)
ISSN:	1550-8080
Popis:	Here we present the case of a 73-year-old male with rectal adenocarcinoma with heterotopic ossification (HO). Cancer-associated HO in the digestive system is rare. Thus, the precise mechanism and clinicopathological significance of HO have not yet been defined. To clarify the molecular mechanisms of HO, we analyzed the expression levels of signaling molecules related to epithelial-mesenchymal transition (EMT) that lead to ossification in the tumor cells discriminating the ossified area (HO-area) and non-ossified area (non-HO area). Expression levels of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2bb894a8bb383766deb72f1a970602b1 https://pubmed.ncbi.nlm.nih.gov/33941570 Zobrazit plný text záznamu