The delta1-opioid receptor antagonist, 7-(benzospiroindanyl)naltrexone [correction of 7-benzylspiroindanylnaltrexone], prolongs renal allograft survival in a rat model

Autor:	K M, Linner, B J, Stickney, H E, Quist, B M, Sharp, P S, Portoghese
Rok vydání:	1998
Předmět:	Dose-Response Relationship Drug Rats Inbred Lew Narcotic Antagonists Receptors Opioid delta Graft Survival Animals Spiro Compounds Rats Inbred BUF Kidney Transplantation Naltrexone Rats
Zdroj:	European journal of pharmacology. 354(1)
ISSN:	0014-2999
Popis:	In this study we demonstrate allograft survival in a rat model of renal transplantation using the delta1-opioid receptor antagonist, 7-(benzospiroindanyl)naltrexone [corrected]. Treatment with 7-(benzospiroindanyl)naltrexone [corrected] caused 50% of the rats to survive longer than 100 days (untreated, 11 +/- 3 days). Naltrindole, a delta-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at delta1-opioid receptors is involved in allograft survival.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2bafb74520db21a161b521f38c0b1e35 https://pubmed.ncbi.nlm.nih.gov/9726640 Zobrazit plný text záznamu Full Text from ScienceDirect