| Autor: |
P, De Paoli, S, Battistin, M, Reitano, C, Castiglia, G F, Santini |
| Rok vydání: |
1984 |
| Předmět: |
|
| Zdroj: |
Bollettino dell'Istituto sieroterapico milanese. 63(3) |
| ISSN: |
0021-2547 |
| Popis: |
Peripheral blood lymphocytes of 8 tetanus patients have been studied with monoclonal antibodies and flow cytometry. During the progression of the disease OKT3+ and Leu7+ cells undergo significative daily variations and OKT4+ cells become the majority of peripheral blood T cells. In two patients is present a severe T lymphopenia and one of these subjects presented a more prolonged disease compared to the other ones. B cells are greatly increased after 10-12 days. Two possibilities could be considered to explain our data: firstly a direct effect of the tetanic infection on the recirculation of lymphocytes producing also an expansion of OKT4+ cells containing a helper population; secondly the observed alterations of lymphocytes subsets are not due to the infection itself but rather to the massive administration of specific immunoglobulins to these patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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