| Autor: |
Jeongwoo, Sim, Bokyeong, Ryou, Minyeong, Choi, Changju, Lee, Cheol-Min, Park |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Organic letters. 24(23) |
| ISSN: |
1523-7052 |
| Popis: |
We describe the electrochemical α-amidoalkylation of γ-lactams based on transition-metal-free cross-coupling via hydrogen atom transfer. The highly selective hydrogen atom transfer process allows for a broad substrate scope including both inter- and intramolecular reactions. Also, the construction of quaternary centers was realized by a double hydrogen atom transfer protocol to afford spirocycles. Detailed mechanistic studies including experimental and computational studies are provided to support the reaction pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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