HLA-F polymorphisms in a Euro-Brazilian population from Southern Brazil

Autor:	L F S, Manvailer, P F, Wowk, S B, Mattar, J S, da Siva, M, da Graça Bicalho, V M M S, Roxo
Rok vydání:	2014
Předmět:	Male Polymorphism Genetic Genotype Histocompatibility Antigens Class I Humans Female Databases Nucleic Acid Alleles Brazil Linkage Disequilibrium
Zdroj:	Tissue antigens. 84(6)
ISSN:	1399-0039
Popis:	HLA-F is a non-classical major histocompatibility complex (MHC) gene. It codes class Ib MHC molecules with restricted distribution and less nucleotide variations than MHC class Ia genes. Of the 22 alleles registered on the IMGT database only four alleles encode for proteins that differ in their primary structure. To estimate genotype and allele frequencies, this study targeted on known protein coding regions of the HLA-F gene. Genotyping was performed by Sequence Base Typing (SBT). The sample was composed by 199-unrelated bone marrow donors from the Brazilian Bone Marrow Donor Registry (REDOME), Euro-Brazilians, from Southern Brazil. About 1673 bp were analyzed. The most frequent allele was HLA-F*01:01 (87.19%), followed by HLA-F*01:03 (12.31%), HLA-F*01:02 (0.25%) and HLA-F*01:04 (0.25%). Significant linkage disequilibrium (LD) was verified between HLA-F and HLA classes I and II alleles. This is the first study regarding HLA-F polymorphisms in a Euro-Brazilian population contributing to the Southern Brazilian genetic characterization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2b8a77cf967e86df31e3e94f3f867f08 https://pubmed.ncbi.nlm.nih.gov/25413105 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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