| Autor: |
J, Fareh, J M, Cottet-Emard, J M, Pequignot, G, Jahns, J, Meylor, M, Viso, D, Vassaux, G, Gauquelin, C, Gharib |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Aviation, space, and environmental medicine. 64(6) |
| ISSN: |
0095-6562 |
| Popis: |
The norepinephrine (NE) content in discrete brain areas and the vasopressin content in the neurohypophysial system were assessed in rats after a 9-d spaceflight and after a recovery period (9 d). The NE content in the locus coeruleus decreased significantly in spaceflight rats (2.9 +/- 0.3 vs. 8.9 +/- 0.7 pmol.structure-1 for control rats, p0.001), but showed no difference between control and flight animals after a 9-d recovery. These findings were probably due to an acute stress undergone during landing. The NE content was unchanged in the A2 and A5 cell groups. In rats flown aboard SLS-1, the vasopressin content was increased in the posterior pituitary (1.47 +/- 0.1 vs. 0.86 +/- 0.1 micrograms.structure-1, for control rats, p0.01), and was significantly decreased in the hypothalamus (8.95 +/- 2.0 vs. 17.6 +/- 2.2 ng.structure-1, for control rats, p0.05). We conclude that the NE depletion in the locus coeruleus and the alteration in vasopressin release were consistent with an acute stress, likely occurring during and/or after landing. These changes tend to mask the actual neuroendocrine modifications caused by microgravity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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