| Autor: |
M Kh, Gaĭnutdinov, R N, Ishmukhamedov, V, Konov, M B, Luchenko, S, Mirmakhmudova |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
Biokhimiia (Moscow, Russia). 53(2) |
| ISSN: |
0320-9725 |
| Popis: |
A thermostable low molecular weight glycopeptide containing syalic acids, which uncouples mitochondrial oxidative phosphorylation, has been detected, isolated and purified from rat liver cytoplasm. In the presence of the glycopeptide, oxidative phosphorylation in rat liver mitochondria is uncoupled by low physiological concentrations of Ca2+, which otherwise do not have any appreciable effect on the mitochondria. Oxidative phosphorylation uncoupling by the glycopeptide is accompanied by an increase of the mitochondrial volume. This process has a limited amplitude and is regulated by changes in Ca2+ concentration in the extramitochondrial space. The glycopeptide has been shown to induce K+ transport across the inner mitochondrial membrane, this effect is enhanced by Ca2+. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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