| Autor: |
Samuel, Hess, Anura, Rambukkana |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Microbiology spectrum. 7(4) |
| ISSN: |
2165-0497 |
| Popis: |
The mammalian nervous system is invaded by a number of intracellular bacterial pathogens which can establish and progress the infection in susceptible individuals. Subsequent clinical manifestation is apparent with the impairment of the functional units of the nervous system; the neurons and the supporting glial cells that produce myelin sheaths around axons and provide trophic support to axons/neurons. Most of these neurotrophic bacteria display unique features and have co-evolved with the functional sophistication of the nervous system cells and have remarkably adapted to manipulate neural cell functions for bacterial advantage. Understanding how these bacterial pathogens establish intracellular adaptation by hijacking endogenous pathways in the nervous system and initiate myelin damage and axonal degeneration provides new knowledge not only to develop strategies to combat neurodegenerative conditions induced by these pathogens but also to gain novel insights into cellular and molecular pathways that regulate nervous system functions. Since the pathways hijacked by bacterial pathogens may also be associated with other neurodegenerative diseases, it is anticipated that detailed mechanisms of bacterial manipulation of neural systems may shed light into common mechanisms, particularly of early disease events. This chapter details a classic example of neurodegeneration caused by Mycobacterium leprae that primarily infect glial cells of the peripheral nervous system, Schwann cells, and how it targets and adapts intracellularly by reprogramming Schwann cells to stem cell/progenitor cells. We finally discuss implications of this host cell reprogramming by leprosy bacilli as a model in a wider context. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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