| Popis: |
Molecular mechanisms of sex hormones (progesterone, medroxyprogesterone acetate (MPA), and new synthetic gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methylpregna-4,6-dien-20-on (ABMP) with human serum albumin, globulins, and calf embryo serum were studied. The binding of ABMP to albumin and progesterone-binding proteins were investigated using spectroscopic techniques (with the use of 1-anilino-8-naphthalenesulfonate as fluorescent probe) and radiolabeled progesterone, (either progesteron or MPA as comparative progestines). There is no difference between the non-specific binding of ABMP, progesterone, and MPA, but the ABMP binding is much smaller as compared to the binding of progestines, so that the new progestine ABMP will produce a more effective action on the target tissue than comparative progestines. |
