The -938CA Polymorphism in
| Autor: | Kalliopi, Aggelou, Elena Konstantina, Siapati, Irini, Gerogianni, Zoe, Daniil, Konstantinos, Gourgoulianis, Ioannis, Ntanos, Emmanouel, Simantirakis, Elias, Zintzaras, Vassiliki, Mollaki, George, Vassilopoulos |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Models Genetic Gene Expression Pilot Projects Mycobacterium tuberculosis Middle Aged Polymorphism Single Nucleotide Molecular Typing Risk Factors Case-Control Studies Myeloid Differentiation Factor 88 Odds Ratio Humans Female Genetic Predisposition to Disease Promoter Regions Genetic Tuberculosis Pulmonary Genetic Association Studies Research Article |
| Zdroj: | Disease Markers |
| ISSN: | 1875-8630 |
| Popis: | Introduction. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection. The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. Aim. The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms in TB. Materials and Methods. A total of 103 TB cases and 92 control subjects were genotyped for the MYD88 -938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms. Results. The MYD88 -938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89–11.28, p = 0.01). Conclusions. The MYD88 -938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk. |
| Databáze: | OpenAIRE |
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