[The role of mu- and delta-opiate receptors in resistance of the myocardium to free radical damage]

Autor:	T Iu, Rebrova, L N, Maslov, Iu B, Lishmanov, S V, Tam
Rok vydání:	2001
Předmět:	Free Radicals Myocardium Receptors Opioid mu Enkephalin Ala(2)-MePhe(4)-Gly(5) In Vitro Techniques Myocardial Contraction Rats Oxidative Stress Receptors Opioid delta Animals Lipid Peroxidation Rats Wistar Oligopeptides Enkephalin Leucine
Zdroj:	Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 87(5)
ISSN:	0869-8139
Popis:	I.v. administration of the delta-opioid (OR) receptors' agonists DSLET or DTLET prevented creatine kinase leakage from the rat isolated heart in oxidative stress damage and abolished an increase in myocardial levels of conjugated diens and malondialdehyde. The agonists also prevented a stress-induced augmentation of the superoxide dismutase (SOD) activity. All protective effects of delta-receptor stimulation was completely abolished by the delta OR antagonist ICI 174,864. The data obtained suggest that the cardioprotective effect of the delta OR stimulation in vivo is not mediated via direct cardiac delta OR activation but, probably, rather via some unknown indirect circulating humoral factor(s).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2b13cff40457febceaf5897806018f43 https://pubmed.ncbi.nlm.nih.gov/11452797 Zobrazit plný text záznamu