Design of PPAR-γ agonist based on algal metabolites and the endogenous ligand 15-deoxy-Δ

Autor:	Zhiran, Ju, Mingzhi, Su, Jongki, Hong, Sultan, Ullah, Eun, La Kim, Chang-Hao, Zhao, Hyung Ryong, Moon, Suhkmann, Kim, Jee H, Jung
Rok vydání:	2018
Předmět:	Models Molecular PPAR gamma Structure-Activity Relationship Dose-Response Relationship Drug Molecular Structure Prostaglandin D2 Drug Design Animals Ligands Cells Cultured Rats
Zdroj:	European journal of medicinal chemistry. 157
ISSN:	1768-3254
Popis:	In a previous study, we synthesized endocyclic enone jasmonate derivatives that function as anti-inflammatory and PPAR-γ-activating entities by using key functional moieties of anti-inflammatory algal metabolites. Herein, we designed additional derivatives containing an exocyclic enone moiety that resembles the key structure of the natural PPAR-γ ligand, 15-deoxy-Δ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2adda4c50da3c4650a76016d7702af9f https://pubmed.ncbi.nlm.nih.gov/30193217 Zobrazit plný text záznamu Full Text from ScienceDirect