Expression of Melan-A/MART-1 antigen as a prognostic factor in primary cutaneous melanoma

Autor:	M, Berset, J P, Cerottini, D, Guggisberg, P, Romero, F, Burri, D, Rimoldi, R G, Panizzon
Rok vydání:	2001
Předmět:	Male Skin Neoplasms Time Factors Prognosis Immunohistochemistry Disease-Free Survival Neoplasm Proteins MART-1 Antigen Antigens Neoplasm Multivariate Analysis Disease Progression Humans Female Melanoma
Zdroj:	International journal of cancer. 95(1)
ISSN:	0020-7136
Popis:	In this study we assessed the expression of the Melan-A/MART-1 antigen by immunohistochemistry using monoclonal antibody A103 in 73 primary cutaneous melanomas and its correlation with tumor staging and patient survival. Melan-A/MART-1 was expressed in 90% of primary tumors, with loss of expression increasing with Breslow thickness. Kaplan-Meier analysis demonstrated a significantly reduced disease-free interval and overall survival rate for patients not expressing this antigen. The poor prognosis of such patients was even worse for those presenting with a primary melanoma and a Breslow thickness ofor = 1 mm. Thus, Melan-A/MART-1 is not only a useful and specific additional marker for the diagnosis of primary cutaneous melanoma, but it may also help refine the prognosis of patients with malignant melanoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2abf5ae5bc6b503e84f5e72aabe24c4e https://pubmed.ncbi.nlm.nih.gov/11241315 Zobrazit plný text záznamu Plný text