[Importance of mammography, sonography and MRI for surveillance of neoadjuvant chemotherapy for locally advanced breast cancer]
| Autor: | T, Schlossbauer, M, Reiser, K, Hellerhoff |
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| Jazyk: | němčina |
| Rok vydání: | 2010 |
| Předmět: |
Receptor
ErbB-2 Carcinoma Ductal Breast Contrast Media Breast Neoplasms Middle Aged Image Enhancement Magnetic Resonance Imaging Sensitivity and Specificity Neoadjuvant Therapy Tumor Burden Treatment Outcome Risk Factors Antineoplastic Combined Chemotherapy Protocols Image Processing Computer-Assisted Humans Female Ultrasonography Mammary Follow-Up Studies Mammography Neoplasm Staging |
| Zdroj: | Der Radiologe. 50(11) |
| ISSN: | 1432-2102 |
| Popis: | The aim of this study is to give an overview on the surveillance of response to neoadjuvant chemotherapy in locally advanced breast cancer with mammography, ultrasound and breast MRI.The results of a recently presented study on surveillance in the course of chemotherapy with contrast-enhanced MRI are compared with ratings based on mammography and ultrasound.Contrast-enhanced MRI correlates best with the histological tumor size when compared with mammography and ultrasound. Tumors with a high HER2 score (2+ with positive FISH test or 3+) show a significantly higher response compared to tumors with a lower HER2 score: size p0.01, maximum enhancement p0.01 and area under the curve (AUC) p0.05. Reduction of tumor size and enhancement are complementary parameters and are not correlated to each other (r=0.22).Contrast-enhanced MRI of the breast is a reliable method for quantification of the response to neoadjuvant chemotherapy. The reductions of tumor size and of tumor enhancement are not correlated. Therefore, it may be reasonable to take both aspects for quantification of therapy response into account. Further studies are needed for evaluation of the value of breast MRI as a prognostic factor. |
| Databáze: | OpenAIRE |
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