Reliability of maximal voluntary isometric contraction testing in a multicenter study of patients with amyotrophic lateral sclerosis. Syntex/Synergen Neuroscience Joint Venture rhCNTF ALS Study Group

Autor:	R J, Hoagland, M, Mendoza, C, Armon, R J, Barohn, W W, Bryan, J C, Goodpasture, R G, Miller, G J, Parry, J H, Petajan, M A, Ross
Rok vydání:	1997
Předmět:	Adult Male Double-Blind Method Isometric Contraction Amyotrophic Lateral Sclerosis Humans Female Respiratory Function Tests
Zdroj:	Musclenerve. 20(6)
ISSN:	0148-639X
Popis:	Maximal voluntary isometric contraction (MVIC) is becoming widely used for monitoring disease progression in amyotrophic lateral sclerosis (ALS). We evaluated the variability of MVIC in a large multicenter (29 sites) drug trial in ALS. Intra- and interrater variability were assessed twice during the 19-month study. Intrarater reliability increased from the first to the second test, approaching the reliability reported for a single experienced clinical evaluator, but interrater reliability did not. Multiple clinical evaluators in a single site increased the variability of MVIC measurements. Rigorous quality assurance standards and monitoring of clinical evaluators should be incorporated into the design of multicenter studies using MVIC, since low variability is necessary to detect a modest treatment effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2a79ec949fb6b6c12f20b6253b34cfc7 https://pubmed.ncbi.nlm.nih.gov/9149075 Zobrazit plný text záznamu Plný text