Evaluation of local MCP-1 and IL-12 nanocoatings for infection prevention in open fractures
| Autor: | Bingyun, Li, Bingbing, Jiang, Matthew J, Dietz, E Suzanne, Smith, Nina B, Clovis, K Murali Krishna, Rao |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Staphylococcus aureus Prosthesis-Related Infections Osteomyelitis Staphylococcal Infections Prosthesis Design Interleukin-12 Internal Fixators Peptide Fragments Article Fracture Fixation Intramedullary Nanostructures Rats Rats Sprague-Dawley Disease Models Animal Fractures Open Adjuvants Immunologic Coated Materials Biocompatible Drug Resistance Bacterial Animals Nanotechnology Femoral Fractures Chemokine CCL2 Bone Wires |
| Zdroj: | Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 28(1) |
| ISSN: | 1554-527X |
| Popis: | The increasing incidence of bacterial infection and the appearance of Staphylococcus aureus (S. aureus) strains that are resistant to commonly used antibiotics has made it important to develop non-antibiotic approaches for infection prevention. The aim of this study was to develop local monocyte chemoattractant protein-1 (MCP-1) and interleukin-12 p70 (IL-12 p70) therapies to prevent S. aureus infection by enhancing the recruitment and activation of macrophages, which are believed to play an important role in infection prevention as the first line of defense against invading pathogens. Nanocoating systems for MCP-1 and IL-12 p70 deliveries were prepared, and their release characteristics desirable for infection prevention in open fractures were explored. Local MCP-1 therapy reduced S. aureus infection and influenced white blood cell populations, and local IL-12 p70 treatment had a more profound effect on preventing S. aureus infection. No synergistic relationship in decreasing S. aureus infection was observed when MCP-1 and IL-12 p70 treatments were combined. This reported new approach may reduce antibiotic use and antibiotic resistance. |
| Databáze: | OpenAIRE |
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