[Chemoradiotherapy in the combined treatment for laryngopharyngeal cancer]
| Autor: | E L, Choĭnzonov, S Iu, Chizhevskaia, L N, Balatskaia |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Squamous Cell Carcinoma of Head and Neck Remission Induction Laryngectomy Pharyngeal Neoplasms Chemoradiotherapy Adjuvant Kaplan-Meier Estimate Vocal Cords Middle Aged Disease-Free Survival Neoadjuvant Therapy Treatment Outcome Pharyngectomy Vocal Cord Dysfunction Head and Neck Neoplasms Antineoplastic Combined Chemotherapy Protocols Carcinoma Squamous Cell Humans Speech Female Laryngeal Neoplasms Aged Neoplasm Staging |
| Zdroj: | Voprosy onkologii. 60(4) |
| ISSN: | 0507-3758 |
| Popis: | The study included 62 patients with morphologically verified squamous cell carcinoma of laryngopharynx, stages T2-4N0-2M0. As a result of the treatment complete regression was recorded in 28.1 ± 7.9% of cases, partial regression--in 50.0 ± 8.8% of patients, and stabilization--in 21.9 ± 7.3% of cases. The total efficiency of therapy made up 78.1 ± 7.3%. Chemotherapy complications and radiation injuries did not exceed I-II grade by CTC-NCIC criteria and PTOG/EORTC scale, were easily stopped, did not affect the time periods of further treatment and had no considerable influence on the postoperative period. Conservative surgery was performed in 26% of cases. The total 5-year survival rate made up 65.4 ± 8.4%, relapse-free 5-year survival rate--60.6 ± 8.9%. The efficiency of the vocal function rehabilitation made up 73.9 ± 9.1%. Rehabilitation time was 21 ± 8.2 days. |
| Databáze: | OpenAIRE |
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