| Autor: |
O Y, Agapova, Y S, Skoblov, G A, Tkachev, N A, Mironova, S P, Golitsyn, V P, Masenko, I E, Chazova, K A, Zykov |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Molekuliarnaia biologiia. 50(6) |
| ISSN: |
0026-8984 |
| Popis: |
Changes in the activity of β2-adrenergic receptors of human T-lymphocytes under the effect of salbutamol (a short-acting β2-agonist) have been evaluated with a new modified radioligand method utilizing [^(125)I]cyanopindolol and a specific ligand ICI 118551. In healthy volunteers, the receptor activity decreased after 30 min upon the inhalation of salbutamol and restored to the initial level after 2 h. At the same time, there were changes in the transcription level of the ADRB2 gene, which encodes the protein component of the β2-adrenoreceptor. The dynamics of β2-adrenergic receptor activity of T-lymphocytes after salbutamol treatment in patients with cardiorespiratory pathology significantly differed from that in healthy volunteers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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