| Autor: |
Shaoming, Zhu, Wei, Li, Xiao, Yang, Weimin, Yu, Ting, Rao, Yuan, Ruan, Jinzhuo, Ning, Run, Yuan, Haoyong, Li, Kun, Jiang, Chenglong, Li, Fan, Cheng |
| Rok vydání: |
2018 |
| Zdroj: |
American journal of translational research. 10(12) |
| ISSN: |
1943-8141 |
| Popis: |
Varicocele (VC) is a common cause of male infertility. An increasing number of studies have confirmed that chronic hypoxia plays an important role in male infertility caused by VC. Our previous study suggested that autophagy may have a crucial function in VC. Whether autophagy plays an important role in hypoxic spermatogonia remains unknown. We established a new method to study VC by culturing spermatogonia under hypoxic conditions to simulate the chronic hypoxic environment of VC. Moreover, the effects of autophagy on hypoxic spermatogonia were observed by regulating autophagy. Spermatogonia from GC-1 spg mice were cultured in vitro in chronic hypoxic conditions (2% O |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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