Effects of interferon-beta 1a on the hypothalamic-pituitary-adrenal axis, leukocyte distribution and mood states in multiple sclerosis patients: results of a 1-year follow-up study
| Autor: | Marion U, Goebel, Frank, Czolbe, Holger, Becker, Onno E, Janssen, Manfred, Schedlowski, Volker, Limmroth |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System Multiple Sclerosis Time Factors Hydrocortisone Pituitary-Adrenal System Cell Count Interferon-beta Middle Aged Body Temperature Affect Disability Evaluation Adjuvants Immunologic Adrenocorticotropic Hormone Leukocytes Humans Female Mental Status Schedule Fatigue Interferon beta-1a Follow-Up Studies |
| Zdroj: | European neurology. 53(4) |
| ISSN: | 0014-3022 |
| Popis: | Acute interferon-beta (IFN-beta) administration transiently activates the hypothalamic-pituitary-adrenal (HPA) axis, increases granulocytes, and reduces lymphocytes in peripheral blood. To test whether these effects are still present after long-term treatment, 13 patients with relapsing-remitting multiple sclerosis were analyzed at baseline, and 1, 2, 4, and 8 h after IFN-beta 1a injection at two occasions: at the initial administration and after 1 year of continuous treatment. Long-term treatment reduced the responsiveness of the HPA axis to the injection, and abolished the distributional changes in leukocyte numbers. One-year treatment with IFN-beta 1a did not induce mood alterations as assessed by the Profile of Mood States. These results suggest that long-term IFN-beta therapy has a profound impact on leukocyte distribution and the neuroendocrine response to the drug. |
| Databáze: | OpenAIRE |
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