| Autor: |
T O, Akande, J O, Adeleye, N, Sepu, O I, Awofisoye |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
African journal of medicine and medical sciences. 45(3) |
| ISSN: |
0309-3913 |
| Popis: |
Autoimmune diseases including thyroid. disorders, type 1 diabetes and celiac disease are commoner in persons with Down's syndrome compared with the general population. Coexistent type 1 diabetes and hyperthyroidism in Down's syndrome is however not commonly reported in literature.To report a case of a lady presenting with Graves' disease and type 1 diabetes at the same time.We report the case of a 22- year-old lady with Down's syndrome who presented with weight loss, polyuria and polydipsia. Physical examination revealed typical dysmorphicfacies of Down's syndrome and a goitre. Laboratory data revealed hyperglycaemia (random plasma glucose-331 mg/dl). She also had biochemical evidence in keeping with hyperthyroidism and markedly elevated thyroid peroxidase antibodies (1087.0 IU/ml). She improved after rehydration, insulin therapy and antithyroid drugs.Coexisting autoimmune diseases may present in patients with Down's syndrome. We advocate for routine screening for diabetes and thyroid dysfunction in ersons with Down's syndrome. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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