The transmembrane channel-like protein family and human papillomaviruses

Autor:	Horton, Jaime S, Stokes, Alexander J
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	cutaneous squamous cell carcinoma Epidermodysplasia verruciformis EVER1 EVER2 TMC6 Author's View papillomavirus TMC8
Zdroj:	Oncoimmunology
ISSN:	2162-402X 2162-4011
Popis:	Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by increased sensitivity to infection by the β-subtype of human papillomaviruses (β-HPVs), causing persistent, tinea versicolor-like dermal lesions. In a majority of affected individuals, these macular lesions progress to invasive cutaneous squamous cell carcinoma (CSCC) in sun-exposed areas. While mutations in transmembrane channel-like 6 (TMC6 / EVER1) and 8 (TMC8 / EVER2) have been causally linked to EV, their molecular functions are unclear. It is likely that their protective effects involve regulation of the β-HPV life cycle, host keratinocyte apoptosis vs. survival balance and/or T-cell interaction with infected host cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::29c69bbcf65cde7a87a3f0aadd6c4161 http://europepmc.org/articles/PMC4006860 Zobrazit plný text záznamu