| Autor: |
Fang, Wang, Ming, Zhang, Bing-Feng, Xie, Han, Cao, Shao-Yong, Tong, Jun-Rong, Wang, Xiao-Ping, Yu, Yang, Tang, Jing-Ran, Yang, Ming-Bo, Sun |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology. 27(2) |
| ISSN: |
1003-9279 |
| Popis: |
To study the effect of aluminume adjuvant and immunization schedule on immunogenicity of Sabin inactivated poliovirus vaccine.Four batches of Sabin IPV were produced by different concentrations of type 1, 2, and 3 poliovirus and administrated on three-dose schedule at 0, 1, 2 months and 0, 2, 4 months on rats. Serum samples were collected one month after each dose and neutralizing antibody titers against three types poliovirus were determined by micro-neutralization assay.The GMTs of neutralizing antibodies against three types poliovirus increased significantly and the seropositivity rates were 100% in all groups after 3 doses. There was no significant difference between two immunization schedules, and the 0, 2, 4 month schedule could induce higher level neutralizing antibody compared to the 0, 1, 2 month schedule. The groups with aluminum adjuvant could induce higher level neutralizing antibody compared to the groups without adjuvant.Aluminum djuvant and immunization schedule could improve the immunogenicity of Sabin IPV. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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