| Autor: |
R Iu, Il'iuchenok, N I, Dubrovina, E V, Popova |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. 51(4) |
| ISSN: |
0044-4677 |
| Popis: |
Using the methods of agonistic confrontations of C57BL/6J mice for formation of aggressive and submissive types of behavior and passive avoidance training we investigated the influence of activation of dopamine presynaptic receptors on retention of a memory trace during extinction and amnesia. Autoreceptor agonist (+)3PPP (2 mg/kg, intraperitoneal injection) impaired learning and retention of a memory trace during extinction and strengthened the amnestic influence of animal detention in a dangerous compartment on the training day only in aggressive mice. In submissive mice, (+) 3PPP improved the retrieval of passive avoidance during extinction but did not change the development of amnesia. This work was the first to demonstrate that the effects of dopamine autoreceptor activation on the passive avoidance retrieval depend on behavioral stereotype (aggressive or submissive). It is suggested that different basic states of the dopaminergic system in aggressive and submissive mice are responsible for different (+) 3PPP effects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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