| Autor: |
A, Lotze, C Y, Stroud, S J, Soldin |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Clinical chemistry. 41(8 Pt 1) |
| ISSN: |
0009-9147 |
| Popis: |
Serial tracheal aspirate samples were obtained for determination of lecithin/sphingomyelin (L/S) ratios from 47 term infants in respiratory failure. Phospholipids were extracted with Folch solution (chloroform:methanol, 2:1 by vol) and analyzed by HPLC with use of silica column and a mobile phase of acetonitrile:methanol:water (48:31:21, by vol). Surfactant/albumin (S/A) ratios were determined with the TDx Fetal Lung Maturity Assay (Abbott Labs). L/S ratios increased significantly over time in all patients (F = 19.42, P0.0001). The S/A ratio correlated with the L/S ratio (r = 0.554, P0.001). This study suggests that postnatal surfactant deficiency in term newborns with respiratory failure is a component of the newborn's lung injury. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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