Contribution of ¹⁸Fluorodeoxyglucose positron emission tomography uptake and TTF-1 expression in the evaluation of the EGFR mutation in patients with lung adenocarcinoma
| Autor: | Zehra Dilek, Kanmaz, Gülfidan, Aras, Esin, Tuncay, Ayşe, Bahadır, Celalettin, Kocatürk, Zehra Asuk, Yaşar, Büge, Öz, Canan Ünlü, Özkurt, Cihan, Gündoğan, Tevfik Fikret, Çermik |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Lung Neoplasms Base Sequence Thyroid Nuclear Factor 1 Nuclear Proteins Adenocarcinoma of Lung Sequence Analysis DNA Adenocarcinoma Middle Aged ErbB Receptors Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Mutation Humans Female Lung Retrospective Studies Transcription Factors |
| Zdroj: | Cancer biomarkers : section A of Disease markers. 16(3) |
| ISSN: | 1875-8592 |
| Popis: | The aim of this study is to evaluate the diagnostic value of PET-CT scan for the prediction of EGFR mutation status and the contribution of TTF-1 expression to PET-CT scan.We retrospectively studied 218 cases with a diagnosis of pulmonary adenocarcinoma between 2012-2014 which underwent EGFR analysis, TTF-1 and PET-CT before treatment.The EGFR mutation was present in 28.9% (n= 63) of cases. TTF-1 positivity was 66.9% (n= 105). Standardized uptake value (SUV max) was 16.7 ± 6.8 in EGFR mutant type, 13.8 ± 7.6 in cases having no EGFR mutations. According to our evaluations, high SUVmax is positively correlated with EGFR mutation status. TTF-1 expression in multivariate analysis strengthens the accuracy of detecting an EGFR mutation.PET-CT FDG uptake may, together with TTF-1 expression, help diagnosis in lung adenocarcinoma cases when evaluating for EGFR mutation status. |
| Databáze: | OpenAIRE |
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