The Effect of Janus Kinase Inhibitors and Phosphodiesterase-4 Inhibitors on Skin and Plasma Cytokine Levels in Patients with Psoriasis

Autor:	O G, Artamonova, A E, Karamova, A A, Nikonorov, D A, Verbenko, E L, Vasileva, A A, Kubanov
Rok vydání:	2020
Předmět:	Adult Male Middle Aged Severity of Illness Index Thalidomide Cohort Studies Young Adult Pyrimidines Treatment Outcome Piperidines Cytokines Humans Janus Kinase Inhibitors Psoriasis Female Phosphodiesterase 4 Inhibitors Skin
Zdroj:	Bulletin of experimental biology and medicine. 171(2)
ISSN:	1573-8221
Popis:	In patients with moderate-to-severe and severe psoriasis and high efficacy of therapy (PASI≥75) with signaling pathway inhibitors (apremilast, tofacitinib), cytokine spectra in the skin and blood plasma were studied using xMAP technology at baseline and on weeks 14 and 26 of treatment. Comparison of cytokine levels in psoriatic lesional skin and plasma samples of patients treated with apremilast or tofacitinib revealed statistical difference only for IFNγ level (р0.05) at week 26.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::293d7e00f0fcfd20bbe074c7d241ff7e https://pubmed.ncbi.nlm.nih.gov/34173094 Zobrazit plný text záznamu Full text from SpringerLink