Characterization of virologic rebound following nirmatrelvir-ritonavir treatment for COVID-19

Autor: Julie, Boucau, Rockib, Uddin, Caitlin, Marino, James, Regan, James P, Flynn, Manish C, Choudhary, Geoffrey, Chen, Ashley M, Stuckwisch, Josh, Mathews, May Y, Liew, Arshdeep, Singh, Zahra, Reynolds, Surabhi L, Iyer, Grace C, Chamberlin, Tammy D, Vyas, Jatin M, Vyas, Sarah E, Turbett, Jonathan Z, Li, Jacob E, Lemieux, Amy K, Barczak, Mark J, Siedner
Rok vydání: 2022
Zdroj: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
ISSN: 1537-6591
Popis: We enrolled seven individuals with recurrent symptoms or antigen test conversion following nirmatrelvir-ritonavir treatment. High viral loads (median 6.1 log10 copies/mL) were detected after rebound for a median of 17 days after initial diagnosis. Three had culturable virus for up to 16 days after initial diagnosis. No known resistance-associated mutations were identified.
Databáze: OpenAIRE