| Autor: |
M, Johansen, K E, Rasmussen, A S, Christophersen, B, Skuterud |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Acta pharmaceutica Nordica. 3(2) |
| ISSN: |
1100-1801 |
| Popis: |
A study of pholcodine metabolism in man is reported. Three subjects received a single therapeutic oral dose of 50 mg pholcodine and urine samples were collected as long as a positive opiate response could be detected by EMIT (16-26 days). Pholcodine was found to conjugate with glucuronic acid and 15% (13-17%) of the pholcodine dose was excreted in urine as the glucuronide, and 29% (24-35%) as unconjugated pholcodine. Morphine was detected to be a metabolite of pholcodine and 0.5-1% of the pholcodine dose was excreted as morphine glucuronide. The identity of morphine was confirmed by capillary gas chromatography-mass spectroscopy (GC-MS). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
