| Autor: |
Rui, Kang, Daolin, Tang, Michael T, Loze, Herbert J, Zeh |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Autophagy. 7(1) |
| ISSN: |
1554-8635 |
| Popis: |
The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin gene superfamily, encoded within the major histocompatability complex class III region. Its multiple ligands include the high mobility group box 1 chromatin binding protein, HMGB1. Recently we reported that RAGE-HMGB1 critically regulates autophagy and apoptosis in pancreatic cancer cells in vivo and in vitro in response to chemotherapy. RAGE inhibits apoptosis ("programmed cell death") by a p53 transcription-independent pathway during the response to chemotherapeutic agents. RAGE sustains autophagy ("programmed cell survival") associated with decreased phosphorylation of the mammalian target of rapamycin (mTOR) and increased Beclin 1-Vps34 interaction. These findings provide insight into how autophagy- and apoptosis-crossregulatory molecules interact in response to cellular stress including tumor therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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