| Autor: |
Y S, Martinova, D B, Nikolova, Z, Michova |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Zeitschrift fur mikroskopisch-anatomische Forschung. 103(3) |
| ISSN: |
0044-3107 |
| Popis: |
Biocarbazin (DTIC synonym) is an anticancer drug acting as a purine analogue, as an alkylating agent, as a SH-group blocker. Biocarbazin administration in doses 50 and 200 mg/kg of body weight to adult male BALB/c mice suppresses the process of spermatogenesis. Seminiferous tubule of the testis displayed dose-dependent histological alterations manifested with decrease of mitotically dividing cells and increase in the number of multinucleated spermatocytes and spermatids. RNA synthetic activity studied by means of autoradiography showed a tendency for a reduction in the spermatogonia and pachytene spermatocytes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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