| Autor: |
R C, Williams, I, van de Rijn, F, Mahros, Z H, Abdin, H, Reid, T, Poon-King |
| Rok vydání: |
1980 |
| Předmět: |
|
| Zdroj: |
The Journal of laboratory and clinical medicine. 96(5) |
| ISSN: |
0022-2143 |
| Popis: |
Peripheral blood lymphocytes binding CRP and streptococcal membrane antigens were studied in 19 patients with ARF with the use of a number of paired analyses for cell surface markers. A small fraction (6.9%) of T cells showed binding to streptococcal membrane. A large degree of overlap (38% to 46%) occurred in membrane-binding T cells and those with identifiable CRP. One third of T gamma cells showed CRP bindings, and approximately one quarter to T gamma cells in both ARF patients and normal controls showed membrane la antigen. A considerable concordance (50% to 75%) was noted between T cells binding streptococcal membrane and cells positive for la antigen. In contrast to T cells, B cells bearing CRP showed less overlap (mean 11%) with cells binding streptococcal membrane. Since B cells with concomitant surface immunoglobulin and la antigen constituted the major lymphocyte subpopulation binding streptococcal membrane antigens, relative exclusion of streptococcal membrane binding by B cells with surface CRP may represent natural protective modulation whereby proportions of potential antigen-binding B cells are defused by lymphocyte membrane CRP. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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