| Autor: |
Guisen, Dai, Shaoxin, Shen, Yongsheng, Liu, Xijing, Ma, Yingbing, Fang, Yixin, Weng, Chunying, Li |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 26(4) |
| ISSN: |
2241-6293 |
| Popis: |
Hepatocellular carcinoma (HCC) is a histological type of primary liver cancer, with high recurrence and mortality rates worldwide. At the moment, there are no diagnostic and prognostic markers. microRNAs (miRs) are short-chain non-coding RNAs, and play a vital role in tumor diagnosis and prognosis.The miR-187 and miR-509-3p expression in primary HCC was evaluated via qRT-PCR and starBase, and the diagnostic and prognostic values were analyzed via receiver operating characteristic (ROC) curve and Kaplan-Meier method.qRT-PCR and starBase analysis showed that the miR-187 expression was low in the tissues and serum of primary HCC patients, while that of miR-509-3p increased. ROC analysis manifested that the area under the curves (AUCs) of miR-187 and miR-509-3p in primary HCC were 0.842 and 0.866, respectively, and that of joint diagnosis was0.9. The 5-year survival rates of miR-187 low expression group and miR-509-3p high expression group decreased markedly. Cox regression analysis identified that pathological differentiation, clinical stage and miR-187 were independent prognostic factors of primary HCC patients.miR-187 and miR-509-3p. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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