Local energy depletion in the basal forebrain increases sleep

Autor:	Anna V, Kalinchuk, Anna-Sofia, Urrila, Lauri, Alanko, Silja, Heiskanen, Henna-Kaisa, Wigren, Maricel, Suomela, Dag, Stenberg, Tarja, Porkka-Heiskanen
Rok vydání:	2003
Předmět:	Male Analysis of Variance Adenosine Dose-Response Relationship Drug Uncoupling Agents Microdialysis Electroencephalography Circadian Rhythm Rats Prosencephalon Pyruvic Acid Animals Sleep Deprivation Lactic Acid Sleep Stages Enzyme Inhibitors 2 4-Dinitrophenol Energy Metabolism Potassium Cyanide Sleep Chromatography High Pressure Liquid
Zdroj:	The European journal of neuroscience. 17(4)
ISSN:	0953-816X
Popis:	Sleep saves energy, but can brain energy depletion induce sleep? We used 2,4-dinitrophenol (DNP), a molecule which prevents the synthesis of ATP, to induce local energy depletion in the basal forebrain of rats. Three-hour DNP infusions induced elevations in extracellular concentrations of lactate, pyruvate and adenosine, as well as increases in non-REM sleep during the following night. Sleep was not affected when DNP was administered to adjacent brain areas, although the metabolic changes were similar. The amount and the timing of the increase in non-REM sleep, as well as in the concentrations of lactate, pyruvate and adenosine with 0.5-1.0 mM DNP infusion, were comparable to those induced by 3 h of sleep deprivation. Here we show that energy depletion in localized brain areas can generate sleep. The energy depletion model of sleep induction could be applied to in vitro research into the cellular mechanisms of prolonged wakefulness.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::28328932fb6599d36e3a6e995dec44fb https://pubmed.ncbi.nlm.nih.gov/12603276 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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