| Autor: |
H, Kolb, M, Oschilewski, E, Schwab, B, Greulich, P, Roos, U, Kiesel |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
Diabetes research (Edinburgh, Scotland). 3(4) |
| ISSN: |
0265-5985 |
| Popis: |
The effect of immunomodulatory lectins on diabetes development following low-dose streptozotocin treatment in inbred mice was studied. All lectins administered had been shown previously to suppress immune reactivity. Among plant lectins concanavalin A but not Lens culinaris or wheat germ agglutinin partially suppressed hyperglycaemia following low-dose streptozotocin. A similar inhibitory effect was found for the staphylococcal enterotoxin B. Finally, administration of an immunomodulatory lectin from vertebrates, electrolectin, also had a beneficial effect on the course of the disease. These findings indicate that some lectins have a suppressive effect on Type 1 diabetes in an animal model. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
