| Autor: |
H F, Pierson, J M, Fisher, M, Rabinovitz |
| Rok vydání: |
1985 |
| Předmět: |
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| Zdroj: |
Research communications in chemical pathology and pharmacology. 50(3) |
| ISSN: |
0034-5164 |
| Popis: |
Dimethyl disulfide markedly increased the cytotoxicity of selenocystamine by 2 orders of magnitude, from 40 microM to 0.5 microM for 50% inhibition of growth in 45 hr. When mice were injected ip with 22 microMole/Kg of selenocystamine on Day 0, all were dead on Day 4. If dimethyl disulfide (500 microMole/Kg) was either mixed with the selenocystamine or injected immediately prior to it, the mice survived treatment for at least 21 days afterwards, suggesting that methylthio-capping of selenocysteamine reduced host toxicity. Such combined treatment may be of value in chemotherapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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