[Correlation between epidermal growth factor and overexpression of vascular endothelial growth factor in hepatocellular carcinoma]
| Autor: | Gengwen, Huang, Lianyue, Yang, Jianqing, Yang, Heli, Liu, Zhili, Yang |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Lymphokines Carcinoma Hepatocellular Epidermal Growth Factor Neovascularization Pathologic Vascular Endothelial Growth Factors Liver Neoplasms Statistics as Topic Endothelial Growth Factors Middle Aged Humans Intercellular Signaling Peptides and Proteins Female Aged |
| Zdroj: | Zhonghua zhong liu za zhi [Chinese journal of oncology]. 24(6) |
| ISSN: | 0253-3766 |
| Popis: | To investigate the correlation between epidermal growth factor (EGF) and overexpression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC).Expressions of EGF, VEGF and microvessel density were studied through immunohistochemical SABC method in 36 HCC specimens, their paraneoplastic liver tissues and 6 normal liver tissues with the correlation between these parameters analyzed. Recombinant human EGF was used to stimulate HepG(2) cells and semi-quantitative reverse transcription PCR was adopted to detect the expression of VEGF in HepG(2) cells.The positive rates of EGF and VEGF expression in HCC tissue were 75.0% and 88.9%. There was positive correlation between EGF and VEGF expression (P0.01, r = 0.462). Recombinant human EGF could induce the expression of VEGF in HepG(2) cells in a dose and time dependent manner.The expression of EGF in HCC underlies the overexpression of VEGF in HCC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|