An amiloride derivative is active against the F

Autor:	Kiel, Hards, Chen-Yi, Cheung, Natalie, Waller, Cara, Adolph, Laura, Keighley, Zhi Shean, Tee, Liam K, Harold, Ayana, Menorca, Richard S, Bujaroski, Benjamin J, Buckley, Joel D A, Tyndall, Matthew B, McNeil, Kyu Y, Rhee, Helen K, Opel-Reading, Kurt, Krause, Laura, Preiss, Julian D, Langer, Thomas, Meier, Erik J, Hasenoehrl, Michael, Berney, Michael J, Kelso, Gregory M, Cook
Rok vydání:	2021
Předmět:	Amiloride Electron Transport Complex IV Adenosine Triphosphate Antitubercular Agents Cytochromes Mycobacterium tuberculosis Oxidoreductases
Zdroj:	Communications biology. 5(1)
ISSN:	2399-3642
Popis:	Increasing antimicrobial resistance compels the search for next-generation inhibitors with differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium tuberculosis has been clinically validated as a promising new drug target for combatting drug-resistant strains of M. tuberculosis. Here, we show that HM2-16F, a 6-substituted derivative of the FDA-approved drug amiloride, is an anti-tubercular inhibitor with bactericidal properties comparable to the FDA-approved drug bedaquiline (BDQ; Sirturo
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::27d4818343c40ab81f2a54807685303c https://pubmed.ncbi.nlm.nih.gov/35210534 Zobrazit plný text záznamu Full text from SpringerLink