Effects of the inhalation of the m3 receptor antagonist bencycloquidium bromide in a mouse cigarette smoke-induced airway inflammation model

Autor:	Shui-Juan, Zhang, Jun-Xia, Jiang, Qian-Qian, Ren, Qiang-Min, Xie, Yao-Kang, Xiong
Rok vydání:	2015
Předmět:	Receptor Muscarinic M3 Mice Inbred ICR Dose-Response Relationship Drug Smoking Pneumonia Bridged Bicyclo Compounds Heterocyclic Disease Models Animal Mice Treatment Outcome Smoke Administration Inhalation Tobacco Animals Female Lung
Zdroj:	Drug development research. 76(3)
ISSN:	1098-2299
Popis:	Bencycloquidium bromide (BCQB), a novel M3 receptor antagonist, alleviates airway hyperresponsiveness, inflammation, and airway remodeling in a murine model of asthma. The aim of this study was to investigate the anti-inflammatory activity of inhaled BCQB in a cigarette smoke (CS)-induced model of acute lung inflammation. Mice exposed to CS developed chronic obstructive pulmonary disease (COPD). Inhalation of BCQB suppressed the accumulation of neutrophils and macrophages in airways and lung and also inhibited the CS-induced increases in mRNA levels of keratinocyte-derived chemokine, monocyte chemotactic protein-1, tumor necrosis factor-alpha, and interleukin-1β in lung and protein expression levels in bronchoalveolar lavage fluid. Moreover, BCQB (300 μg/ml) inhibited the CS-induced changes in superoxide dismutase and myeloperoxidase activities in the lungs. Our study suggests that BCQB might be a potential therapy for inflammation in CS-induced pulmonary diseases, including COPD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::27d1e3df43dd1cca440f9cb4e8610482 https://pubmed.ncbi.nlm.nih.gov/25958838 Zobrazit plný text záznamu Plný text