| Autor: |
Rozália, Pusztai, Judit, Hohmann, Dora, Rédei, Helga, Engi, Joseph, Molnár |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
In vivo (Athens, Greece). 22(6) |
| ISSN: |
0258-851X |
| Popis: |
The development of strategies intended to inhibit human cytomegalovirus (HCMV) immediate-early (IE) antigen expression is an important goal in research designed to prevent and treat certain forms of cancer. The aim of this study was to identify potent IE antigen-targeting natural compounds as antitumor promoters in an in vitro model of tumor promotion. Nineteen dihydro-beta-agarofuran sesquiterpenes isolated from Euonymus species were evaluated for their ability to inhibit HCMV IE antigen expression in human lung adenocarcinoma (A549) cells. Five esters of penta- and hexahydroxydihydro-beta-agarofuran proved to be active components in these Euonymus species, inhibiting the IE antigen expression of HCMV. The highest activity was displayed by 2beta,6alpha,15-triacetoxy1beta-benzoyloxy-9alpha-nicotinoyloxydihydro-beta-agarofuran. These effective compounds may be regarded as prototypes of antitumor promoters, as secondary chemopreventive agents which can modify or halt tumor promotion in general. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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