The new paradigm for coronary artery disease: altering risk factors, atherosclerotic plaques, and clinical prognosis
| Autor: | J H, O'Keefe, R D, Conn, C J, Lavie, T M, Bateman |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Inflammation
Simvastatin Anticholesteremic Agents Adrenergic beta-Antagonists Hypercholesterolemia Angiotensin-Converting Enzyme Inhibitors Coronary Artery Disease Coronary Angiography Prognosis Antioxidants Risk Factors Exercise Test Humans Endothelium Vascular Lovastatin Platelet Aggregation Inhibitors Randomized Controlled Trials as Topic |
| Zdroj: | Mayo Clinic proceedings. 71(10) |
| ISSN: | 0025-6196 |
| Popis: | The old paradigm states that the greater the stenosis, the greater the risk of cardiac events. Revascularization procedures are the only effective approach to improving prognosis associated with coronary artery disease. In contrast, on the basis of the new paradigm, the nature of the plaque determines the risk of acute cardiovascular events. Dangerous plaques have a lipid-rich core with surrounding inflammation and a thin friable overlying fibrous cap, but they usually appear innocuous on angiography. Effective risk factor modification stabilizes the dangerous plaques and is associated with prompt improvement in endothelial dysfunction and a substantial decrease in the risk of acute cardiovascular events and death. |
| Databáze: | OpenAIRE |
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