| Autor: |
R, Panchagnula, I, Singh, K J, Kaur, C L, Kaul |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
Methods and findings in experimental and clinical pharmacology. 21(9) |
| ISSN: |
0379-0355 |
| Popis: |
The benefits of fixed-dose combinations of antituberculosis agents are well recognized by the World Health Organization (WHO) and International Union Against Tuberculosis and Lung Disease (IUATLD) and preferred over separate formulations. Therefore, a comparative bioequivalence study of rifampicin and isoniazid together in a fixed-dose combination and separately (at the same dose levels) was performed on a group of 12 healthy subjects. The study was designed as a single-blind, crossover experiment. Nine blood samples were collected from each subject over a period of 24 h. The plasma concentrations of rifampicin were assessed by a method developed in this laboratory. Various pharmacokinetic parameters of rifampicin such as AUC, Cmax, Tmax and t1/2 were also calculated. The study demonstrates that a fixed-dose combination (test formulation) and separate formulations (standard formulations) are bioequivalent for rifampicin. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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