Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through AChE variants overexpression and NGF/TrkA/P75
| Autor: | Paula, Moyano, Andrea, Flores, Jimena, García, José Manuel, García, María José, Anadon, María Teresa, Frejo, Emma, Sola, Adela, Pelayo, Javier, Del Pino |
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| Rok vydání: | 2021 |
| Předmět: |
Histone Deacetylase 2
Apoptosis Receptors Nerve Growth Factor Real-Time Polymerase Chain Reaction Synaptic Transmission Acetylcholine Cholinergic Neurons Mice Neuroblastoma Phenols Cell Line Tumor Gene Knockdown Techniques Nerve Growth Factor Animals Benzhydryl Compounds Receptor trkA Signal Transduction |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 157 |
| ISSN: | 1873-6351 |
| Popis: | Bisphenol-A (BPA), a widely used plasticizer, induces cognitive dysfunctions following single and repeated exposure. Several studies, developed in hippocampus and cortex, tried to find the mechanisms that trigger and mediate these dysfunctions, but those are still not well known. Basal forebrain cholinergic neurons (BFCN) innervate hippocampus and cortex, regulating cognitive function, and their loss or the induction of cholinergic neurotransmission dysfunction leads to cognitive disabilities. However, no studies were performed in BFCN. We treated wild type or histone deacetylase (HDAC2), P75 |
| Databáze: | OpenAIRE |
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