| Autor: |
D P, Sheridan, R T, Card, J C, Pinilla, S M, Harding, D J, Thomson, L, Gauthier, D, Drotar |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Canadian journal of surgery. Journal canadien de chirurgie. 37(1) |
| ISSN: |
0008-428X |
| Popis: |
To determine whether desmopressin acetate (DDAVP) has the ability to reduce blood loss in patients with a known bleeding tendency.A randomized, double-blind, placebo controlled study.A university teaching hospital.Men under the age of 70 years who had taken acetylsalicylic acid within 7 days of scheduled coronary artery bypass surgery. Patients with an abnormal hematologic profile or a history of bleeding or who were receiving heparin or undergoing repeat coronary bypass surgery were excluded. Forty-four patients were randomized with restriction in blocks of 10; 20 received DDAVP and 24 received a placebo.Blood loss and blood transfusion requirements.Patients treated with DDAVP lost significantly (p0.01) less blood than those receiving a placebo (1543 mL versus 2376 mL respectively). Nineteen patients had a blood loss of more than 2000 mL; 15 of these were in the placebo group. Significantly (p0.02) fewer patients receiving DDAVP required blood transfusion (9 versus 18).DDAVP reduces blood loss during cardiac bypass surgery in patients who have taken acetylsalicylic acid within 7 days before operation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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