Chronic lymphatic leukemia developing in a patient with multiple myeloma: immunologic demonstration of a clonally distinct second malignancy

Autor:	J R, Zalcberg, F N, Cornell, H J, Ireton, K M, McGrath, R, McLachlan, R K, Woodruff, J S, Wiley
Rok vydání:	1982
Předmět:	Male Bone Marrow Humans Immunoglobulins Bone Neoplasms Ribs Lymphocytes Multiple Myeloma Melphalan Aged Leukemia Lymphoid
Zdroj:	Cancer. 50(3)
ISSN:	0008-543X
Popis:	A patient with multiple myeloma who subsequently developed chronic lymphocytic leukemia is reported. Initial studies demonstrated clinical and hematological features of multiple myeloma with an IgM lambda paraprotein. Skeletal disease was a significant presenting feature, although relapse occurred in extraosseous sites, particularly the pleura. He developed chronic lymphatic leukemia 31 months later and immunological studies showed the malignant lymphocytes to have kappa (Kappa) light chain surface immunoglobulin, demonstrating separate clonal origin of this patient's two B-cell malignancies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::277003655654377d1d16dde5b0ff6f22 https://pubmed.ncbi.nlm.nih.gov/7093901 Zobrazit plný text záznamu Plný text