| Autor: |
Ramkripa, Raghavan, Anne W, Riley, Heather, Volk, Deanna, Caruso, Lynn, Hironaka, Laura, Sices, Xiumei, Hong, Guoying, Wang, Yuelong, Ji, Martha, Brucato, Anastacia, Wahl, Tom, Stivers, Colleen, Pearson, Barry, Zuckerman, Elizabeth A, Stuart, Rebecca, Landa, M Daniele, Fallin, Xiaobin, Wang |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Paediatric and perinatal epidemiology. 32(1) |
| ISSN: |
1365-3016 |
| Popis: |
To examine the prospective association between multivitamin supplementation during pregnancy and biomarker measures of maternal plasma folate and vitamin BThis report included 1257 mother-child pairs, who were recruited at birth and prospectively followed through childhood at the Boston Medical Center. ASD was defined from diagnostic codes in electronic medical records. Maternal multivitamin supplementation was assessed via questionnaire interview; maternal plasma folate and BModerate (3-5 times/week) self-reported supplementation during pregnancy was associated with decreased risk of ASD, consistent with previous findings. Using this as the reference group, low (≤2 times/week) and high (5 times/week) supplementation was associated with increased risk of ASD. Very high levels of maternal plasma folate at birth (≥60.3 nmol/L) had 2.5 times increased risk of ASD [95% confidence interval (CI) 1.3, 4.6] compared to folate levels in the middle 80th percentile, after adjusting for covariates including MTHFR genotype. Similarly, very high BThere was a 'U shaped' relationship between maternal multivitamin supplementation frequency and ASD risk. Extremely high maternal plasma folate and B |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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